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Home Antibody All anti-UNC93B1 antibodies

Anti-UNC93B1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306557
  • Rabbit Polyclonal Unc93b Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC410646) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for UNC93B1 (NM_030930)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenUnc93b antibody was raised against a 19 amino acid peptide from near the amino terminus of human Unc93b.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens unc-93 homolog B1 (C. elegans) (UNC93B1)
Alternative NameIIAE1; Unc-93B1; UNC93; UNC93B
Database LinkNP_112192
FunctionThe endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity. Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a.
Related Pathway

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WB Image
Western blot analysis of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of Unc93b in human heart with Unc93b antibody at 2.5 ug/ml.

 

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