Home Antibody All anti-UNC93B1 antibodies
Also for UNC93B1 (NM_030930)
|Unc93b antibody was raised against a 19 amino acid peptide from near the amino terminus of human Unc93b.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens unc-93 homolog B1 (C. elegans) (UNC93B1)|
|IIAE1; Unc-93B1; UNC93; UNC93B|
|The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity. Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a.|
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Western blot analysis of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of Unc93b in human heart with Unc93b antibody at 2.5 ug/ml.