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Home Antibody All anti-DDIT4 antibodies

Anti-DDIT4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306539
  • Rabbit Polyclonal RTP801 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402731) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for DDIT4 (NM_019058)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRTP801 antibody was raised against a 12 amino acid peptide from near the center of human RTP801.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens DNA-damage-inducible transcript 4 (DDIT4)
Alternative NameDig2; REDD-1; REDD1
Database LinkNP_061931
FunctionRTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Related Pathway

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WB Image
Western blot analysis of RTP801 in human kidney tissue lysate with RTP801 antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of RTP801 in mouse kidney tissue with RTP801 antibody at 5 ug/ml.

 

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