Home Antibody All anti-FBXL20 antibodies
Also for FBXL20 (NM_001184906)
|SCRAPPER antibody was raised against a 18 amino acid peptide near the amino terminus of the human SCRAPPER.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens F-box and leucine-rich repeat protein 20 (FBXL20), transcript variant 2|
|Fbl2; Fbl20; RP11-690G19.3|
|Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.|
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Western blot analysis of SCRAPPER in A20 cell lysate with SCRAPPER antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemical staining of human brain tissue using Scrapper antibody at 2.5 ug/ml.