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Home Antibody All anti-FBXL20 antibodies

Anti-FBXL20 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306520
  • Rabbit Polyclonal SCRAPPER Antibody
100ug $325 In Stock
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WB(1)
IHC(1)
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Also for FBXL20 (NM_001184906)
cDNA Clone shRNA/siRNA Primer Pair Protein Request Antibody

OriGene Data

ImmunogenSCRAPPER antibody was raised against a 18 amino acid peptide near the amino terminus of the human SCRAPPER.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens F-box and leucine-rich repeat protein 20 (FBXL20), transcript variant 2
Alternative NameFbl2; Fbl20
Database LinkNP_001171835
FunctionMembers of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
Related Pathway

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WB Image
Western blot analysis of SCRAPPER in A20 cell lysate with SCRAPPER antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemical staining of human brain tissue using Scrapper antibody at 2.5 ug/ml.

 

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