Home Antibody All anti-ATG12 antibodies
Also for ATG12 (NM_004707)
|ATG12 antibody was raised against a 15 amino acid peptide from near the center of human ATG12.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens autophagy related 12 (ATG12), transcript variant 1|
|APG12; APG12L; FBR93; HAPG12|
Entrez Gene 9140 Human
Entrez Gene 67526 Mouse
Entrez Gene 361321 Rat
|Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.|
| Regulation of autophagyRIG-I-like receptor signaling pathway|
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Western blot analysis of ATG12 in mouse heart tissue lysate with ATG12 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of ATG12 in human brain tissue with ATG12 antibody at 2.5 ug/ml.