Home Antibody All anti-GRIK5 antibodies
Also for GRIK5 (NM_002088)
|Grik5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human Grik5.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens glutamate receptor, ionotropic, kainate 5 (GRIK5)|
|EAA2; GluK5; GRIK2; KA2|
|Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface. This Grik5 antibody does not cross-react with Grik4.|
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Western blot analysis of Grik5 in human brain tissue lysate with Grik5 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemical staining of human brain tissue using Grik5 antibody at 2.5 ug/ml.