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Home Antibody All anti-SLC9A1 antibodies

Anti-SLC9A1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306492
  • Rabbit Polyclonal Nhe-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401064) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for SLC9A1 (NM_003047)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenNhe-1 antibody was raised against a 20 amino acid peptide near the carboxy terminus of the human Nhe-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 (SLC9A1), transcript variant 1
Alternative NameAPNH; NHE-1; NHE1; PPP1R143
Database LinkNP_003038
FunctionThe Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
Related Pathway

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WB Image
Western blot analysis of Nhe-1 in rat kidney tissue lysate with in with Nhe-1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemical staining of human brain tissue using Nhe-1 antibody at 2.5 ug/ml.

 

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