Home Antibody All anti-SLC9A1 antibodies
Also for SLC9A1 (NM_003047)
|Nhe-1 antibody was raised against a 20 amino acid peptide near the carboxy terminus of the human Nhe-1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 (SLC9A1), transcript variant 1|
|APNH; NHE-1; NHE1; PPP1R143|
Entrez Gene 6548 Human
Entrez Gene 20544 Mouse
Entrez Gene 24782 Rat
|The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.|
|TransmembraneDruggable Genome Cardiac muscle contractionRegulation of actin cytoskeleton|
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Western blot analysis of Nhe-1 in rat kidney tissue lysate with in with Nhe-1 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemical staining of human brain tissue using Nhe-1 antibody at 2.5 ug/ml.