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Home Antibody All anti-FAM175A antibodies

Anti-FAM175A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306469
  • Rabbit Polyclonal CCDC98 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC408418) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for FAM175A (NM_139076)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenCCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens family with sequence similarity 175, member A (FAM175A)
Alternative NameABRA1; CCDC98
Database LinkNP_620775
FunctionCCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
Related Pathway

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WB Image
Western blot analysis of CCDC98 in human breast tissue lysate in (A) the absence and (B) presence of blocking peptide with CCDC98 antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of CCDC98 in human breast tissue with CCDC98 antibody at 5 ug/ml.

 

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