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Home Antibody All anti-FAM175A antibodies

Anti-FAM175A Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306469 Rabbit Polyclonal CCDC98 Antibody 100ug $325 3-7 Days
LC408418 FAM175A HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenCCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/mL, ICC: 5 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target Namefamily with sequence similarity 175 member A
Alternative NameABRA1|CCDC98
Database LinkNP_620775
Entrez Gene 84142 Human
Entrez Gene 70681 Mouse
FunctionCCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of CCDC98 in human breast tissue lysate in (A) the absence and (B) presence of blocking peptide with CCDC98 antibody at 1 ug/ml.

IHC Image
Immunohistochemistry of CCDC98 in human breast tissue with CCDC98 antibody at 5 ug/ml.


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