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Home Antibody All anti-DISC1 antibodies

Anti-DISC1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306458
  • Rabbit Polyclonal DISC1 Antibody
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenDISC1 antibody was raised against a 13 amino acid peptide from near the amino terminus of human DISC1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens disrupted in schizophrenia 1 (DISC1), transcript variant Lv
Alternative NameC1orf136; SCZD9
Database LinkNP_001012975
Entrez Gene 27185 Human
Entrez Gene 244667 Mouse
FunctionDisrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3e from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DISC1 in 3T3 cell lysate with DISC1 antibody at (A) 1 and (B) 2 µg/ml.

 

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