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Home Antibody All anti-PAFAH1B1 antibodies

Anti-PAFAH1B1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306455
  • Rabbit Polyclonal LIS1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424722) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for PAFAH1B1 (NM_000430)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenLIS1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human LIS1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 1 ug/ml, ICC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) (PAFAH1B1)
Alternative NameLIS1; LIS2; MDCR; MDS; PAFAH
Database LinkNP_000421
FunctionLissencephaly is a severe brain developmental disease characterized by the mislocalization of cortical neurons, a smooth cerebral surface, mental retardation, and seizures. Classical lissencephaly is caused by sporadic mutations in the LIS1 gene. While LIS1 is known to act in a pathway deactivating the lipid messenger platelet-activating factor, LIS1 forms a complex with Nudel and 14-3-3e which is then transported from neuronal cell bodies through the actions of DISC1 and KIF5A, a microtubule-dependent directed motor protein kinesin. Decreased expression of LIS1 blocked neural stem cell division, morphogenesis, and motility, suggesting that LIS1 plays an important role in neuronal cell proliferation and localization in the developing brain. At least two isoforms of LIS1 are known to exist.
Related Pathway
Cell cycle
Wnt Signaling Pathway

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WB Image
Western blot analysis of LIS1 in HeLa cell lysate with LIS1 antibody at (A) 0.5 and (B) 1 ug/mL.
IF Image
Immunocytochemistry of LIS1 in Jurkat cells with LIS1 antibody at 2.5 ug/mL.

 

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