Home Antibody All anti-TARDBP antibodies
Also for TARDBP (NM_007375)
|TDP43 antibody was raised against a 18 amino acid peptide from near the center of human TDP43.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens TAR DNA binding protein (TARDBP)|
|TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3’ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. At least two isoforms are known to exist for this protein; this TDP43 antibody only recongizes the longer of the two isoforms.|
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Western blot analysis of TDP43 in L1210 cell lysate with TDP43 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry of TDP43 in HeLa cells with TDP43 antibody at 5 ug/mL.