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Home Antibody All anti-TACR3 antibodies

Anti-TACR3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306441
  • Rabbit Polyclonal NK3R Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC420739) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenNK3R antibody was raised against a 18 amino acid peptide from near the center of human NK3R.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tachykinin receptor 3 (TACR3)
Alternative NameHH11; NK-3R; NK3R; NKR; TAC3RL
Database LinkNP_001050
FunctionThe tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B. NK3R antibody does not recognize NK1R or NK2R.
Related Pathway
Signaling by GPCR

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WB Image
Western blot analysis of NK3R in RAW264.7 cell lysate with NK3R antibody at (A) 0.5 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of NK3R in human brain tissue with NK3R antibody at 5 ug/ml.

 

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