Home Antibody All anti-ORAI3 antibodies
Also for ORAI3 (NM_152288)
|ORAI3 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human ORAI3.|
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 2 - 4 ug/ml, ICC: 5 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3)|
Entrez Gene 93129 Human
Entrez Gene 269999 Mouse
|Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.|
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Western blot analysis of ORAI3 in A20 cell lysate with ORAI3 antibody at (A) 2 and (B) 4 ug/mL.
Immunocytochemistry of ORAI3 in A20 cells with ORAI3 antibody at 5 ug/mL.