Home Antibody All anti-CRLF2 antibodies
Also for CRLF2 (NM_001012288)
|TSLP Receptor antibody was raised against a 19 amino acid peptide from near the center of human TSLP receptor.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens cytokine receptor-like factor 2 (CRLF2), transcript variant 2|
|CRL2; CRLF2Y; TSLPR|
Entrez Gene 64109 Human
|Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE.|
|Secreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathway|
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Western blot analysis of TSLP Receptor in human liver tissue lysate with TSLP Receptor antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of TSLP-R in human liver tissue with TSLP-R antibody at 5 ug/ml.