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Home Antibody All anti-NRN1 antibodies

Anti-NRN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306415
  • Rabbit Polyclonal Neuritin Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402576) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for NRN1 (NM_016588)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNeuritin antibody was raised against a 20 amino acid peptide from near the center of human neuritin.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens neuritin 1 (NRN1), transcript variant 1
Alternative NamedJ380B8.2; NRN
Database LinkNP_057672
Entrez Gene 51299 Human
Entrez Gene 68404 Mouse
FunctionAs the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of neuritin in Daudi cell lysate with neuritin antibody at (A) 5 and (B) 10 ug/ml.
IHC Image
Immunohistochemistry of Neuritin in mouse heart tissue with Neuritin antibody at 5 ug/ml.

 

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