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Home Antibody All anti-PDCD1 antibodies

Anti-PDCD1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306404
  • Rabbit Polyclonal PD-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401555) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for PDCD1 (NM_005018)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPD-1 antibody was raised against a 16 amino acid peptide from near the center of human PD-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens programmed cell death 1 (PDCD1)
Alternative NameCD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Database LinkNP_005009
FunctionCell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals” such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Related Pathway

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WB Image
Western blot analysis of PD-1 in THP-1 cell lysate with PD-1 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.
IHC Image
Immunohistochemistry of PDCD1 in human brain tissue with PDCD1 antibody at 5 ug/ml.

 

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