Home Antibody All anti-PDCD1 antibodies
Also for PDCD1 (NM_005018)
|PD-1 antibody was raised against a 16 amino acid peptide from near the center of human PD-1.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens programmed cell death 1 (PDCD1)|
|CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2|
Entrez Gene 5133 Human
Entrez Gene 18566 Mouse
Entrez Gene 301626 Rat
|Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals” such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.|
|TransmembraneDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathway|
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Western blot analysis of PD-1 in THP-1 cell lysate with PD-1 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.
Immunohistochemistry of PDCD1 in human brain tissue with PDCD1 antibody at 5 ug/ml.