Home Antibody All anti-PDCD1LG2 antibodies
Also for PDCD1LG2 (NM_025239)
|PDL-2 antibody was raised against a 16 amino acid peptide from near the center of human PDL-2.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens programmed cell death 1 ligand 2 (PDCD1LG2)|
|B7DC; bA574F11.2; Btdc; CD273; PD-L2; PDCD1L2; PDL2|
|Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; this antibody is specific to the largest isoform. PDL-2 antibody has no cross-reactivity to PDL-2.|
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Western blot analysis of PDL-2 in Raji cell lysate with PDL-2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of PDL-2 in mouse brain tissue with PDL-2 antibody at 2.5 ug/ml.