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Home Antibody All anti-ORAI1 antibodies

Anti-ORAI1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306394
  • Rabbit Polyclonal ORAI1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403208) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenORAI1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human ORAI1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1)
Alternative NameCRACM1; IMD9; ORAT1; TAM2; TMEM142A
Database LinkNP_116179
Entrez Gene 84876 Human
Entrez Gene 109305 Mouse
FunctionAntigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at 1 ug/ml in the (A) absence or (B) presence of blocking peptide.
IHC Image
Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 10 ug/ml.

 

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