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Home Antibody All anti-IFIH1 antibodies

Anti-IFIH1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306392 Rabbit Polyclonal MDA5 Antibody 100ug $325 3-7 Days
LC411723 IFIH1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for IFIH1 (NM_022168)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenMDA5 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MDA5.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 4 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interferon induced with helicase C domain 1 (IFIH1)
Alternative NameAGS7; Hlcd; IDDM19; MDA-5; MDA5; RLR-2
Database LinkNP_071451
Entrez Gene 64135 Human
Entrez Gene 71586 Mouse
FunctionThe innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kB. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.
Related Pathway RIG-I-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of MDA5 in Daudi cell lysate with MDA5 antibody at (A) 1, (B) 2 and (C) 4 ug/ml.

IHC Image
Immunohistochemistry of MDA5 in human lymph node tissue with MDA5 antibody at 5 ug/ml.

IF Image
Immunofluorescence of MDA5 in Human Lymph Node cells with MDA5 antibody at 20 ug/mL.


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