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Home Antibody All anti-IFIH1 antibodies

Anti-IFIH1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306392
  • Rabbit Polyclonal MDA5 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411723) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for IFIH1 (NM_022168)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenMDA5 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MDA5.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interferon induced with helicase C domain 1 (IFIH1)
Alternative NameAGS7; Hlcd; IDDM19; MDA-5; MDA5; RLR-2
Database LinkNP_071451
FunctionThe innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kB. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.
Related Pathway

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WB Image
Western blot analysis of MDA5 in Daudi cell lysate with MDA5 antibody at (A) 1, (B) 2 and (C) 4 ug/ml.
IHC Image
Immunohistochemistry of MDA5 in human lymph node tissue with MDA5 antibody at 5 ug/ml.

 

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