Home Antibody All anti-SNAI2 antibodies
Also for SNAI2 (NM_003068)
|Slug antibody was raised against a 14 amino acid peptide from near the center of human Slug .|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens snail family zinc finger 2 (SNAI2)|
|SLUG; SLUGH1; SNAIL2; WS2D|
Entrez Gene 6591 Human
Entrez Gene 20583 Mouse
|Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.|
|Transcription FactorsDruggable Genome Adherens junction|
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Western blot analysis of Slug in human kidney cell lysate with Slug antibody at in (A) 1 and (B) 2 µg/ml.