Home Antibody All anti-IL27 antibodies
Also for IL27 (NM_145659)
|IL-27 antibody was raised against a 14 amino acid peptide from near the center of human IL-27.|
||WB: 2 - 4 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interleukin 27 (IL27)|
|IL-27; IL-27A; IL27A; IL27p28; IL30; p28|
Entrez Gene 246778 Human
Entrez Gene 246779 Mouse
|Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.|
|TransmembraneDruggable Genome |
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Western blot analysis of IL-27 in Daudi lysate with IL-27 antibody at (A) 2 and (B) 4 µg/ml.