Home Antibody All anti-IL23A antibodies
Also for IL23A (NM_016584)
|IL-23 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-23.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens interleukin 23, alpha subunit p19 (IL23A)|
|IL-23; IL-23A; IL23P19; P19; SGRF|
|Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes (3,4). Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-alpha from activated T cells, and can stimulate macrophages to produce TNF-alpha and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.|
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
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Western blot analysis of IL-23 in mouse pancreas tissue lysate with IL-23 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of IL-23 in mouse pancreas tissue with IL-23 antibody at 2 ug/ml.