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Home Antibody All anti-MAP3K5 antibodies

Anti-MAP3K5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306285
  • Rabbit Polyclonal ASK1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401794) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for MAP3K5 (NM_005923)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenASK1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human ASK1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Alternative NameASK1; MAPKKK5; MEKK5
Database LinkNP_005914
Entrez Gene 4217 Human
Entrez Gene 26408 Mouse
FunctionMitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5 (1-3). ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-Α-induced apoptosis. ASK1 is expressed in variety of tissues and cell lines.
Related Pathway
MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ASK1 in 3T3 cell lysate with ASK1 antibody at (A) 1 and (B) 2 µg/ml.

 

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