Home Antibody All anti-TLR5 antibodies
Also for TLR5 (NM_003268)
|TLR5 antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human TLR5.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens toll-like receptor 5 (TLR5)|
|MELIOS; SLE1; SLEB1; TIL3|
Entrez Gene 7100 Human
Entrez Gene 53791 Mouse
|Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-kappaB, leading to the activation of TNF-Α and other cytokines (4). A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response (5).|
|TransmembraneDruggable Genome Toll-like receptor signaling pathwayPathogenic Escherichia coli infection|
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Western blot analysis of TLR5 in THP-1 cell lysate with TLR5 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry of TLR5 in THP-1 cells with TLR5 antibody at 10 ug/mL.