Home Antibody All anti-GOPC antibodies
Also for GOPC (NM_001017408)
|PIST antibody was raised against a 17 amino acid peptide from near the center of human PIST.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens golgi-associated PDZ and coiled-coil motif containing (GOPC), transcript variant 2|
|CAL; dJ94G16.2; FIG; GOPC1; PIST|
|Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (4-6). Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1 (6).|
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Western blot analysis of PIST in PC-3 cell lysate with PIST antibody at (A) 1, (B) 2 and (C) 4 ug/ml.
Immunohistochemistry of PIST in rat colon tissue with PIST antibody at 1 ug/ml.