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Home Antibody All anti-BECN1 antibodies

Anti-BECN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306256
  • Rabbit Polyclonal Beclin-1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401239) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for BECN1 (NM_003766)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBeclin-1 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Beclin-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens beclin 1, autophagy related (BECN1)
Alternative NameATG6; beclin1; VPS30
Database LinkNP_003757
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (3,4), is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors (5). Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death (6).
Related Pathway
Senescence and Autophagy

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Beclin-1 in 293 cell lysate with Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of beclin-1 in rat brain tissue with beclin-1 antibody at 2 ug/ml.

 

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