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Home Antibody All anti-AES antibodies

Anti-AES Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306254
  • Rabbit Polyclonal AES Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420115) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for AES (NM_001130)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenAES antibody was raised against a 16 amino acid peptide from near the amino-terminus of human AES.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 - 4 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens amino-terminal enhancer of split (AES), transcript variant 2
Alternative NameAES-1; AES-2; ESP1; GRG; GRG5; TLE5
Database LinkNP_001121
FunctionAdhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment (1). Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination (2,3). AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis (4). It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. (4). Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin (4).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of AES in 293 cell lysate with AES antibody at (A) 2 and (B) 4 ug/mL.
IF Image
Immunocytochemistry of AES in 293 cells with AES antibody at 10 ug/mL.

 

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