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Also for Irak2 (NM_172161)
|RAK2 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of mouse IRAK2a which is common to all four isoforms. Anti-IRAK2 is mouse specific.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Mus musculus interleukin-1 receptor-associated kinase 2 (Irak2), transcript variant 1|
|6330415L08Rik; AI649099; IRAK-2|
|The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappaB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2 (1). Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappaB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-?B activation (2,3). Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion (4). IRAK2 is expressed in a variety of tissues.|
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Western blot analysis of IRAK2 in A-20 whole cell lysate with IRAK2 antibody (C2) at (A) 0.5, (B) 1, and (C) 2 µg/ml.