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Home Antibody All anti-TSC1 antibodies

Anti-TSC1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306217
  • Rabbit Polyclonal TSC1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400132) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenRabbit TSC1 (CT) polyclonal antibody was raised against a 15 amino acid peptide from the carboxy terminus of human TSC1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tuberous sclerosis 1 (TSC1), transcript variant 1
Alternative NameLAM; TSC
Database LinkNP_000359
Entrez Gene 7248 Human
Entrez Gene 64930 Mouse
FunctionTuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TSC1 in C2C12 cell lysate with TSC1 antibody at (A) 2 and (B) 4 µg.

 

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