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Home Antibody All anti-MLST8 antibodies

Anti-MLST8 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306214
  • Rabbit Polyclonal GBL Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411693) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenGbL antibody was raised against a 14 amino acid peptide from near the carboxy-terminus of human GbL.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens MTOR associated protein, LST8 homolog (S. cerevisiae) (MLST8), transcript variant 1
Alternative NameGbetaL; GBL; LST8; POP3; WAT1
Database LinkNP_071767
Entrez Gene 64223 Human
Entrez Gene 56716 Mouse
Entrez Gene 64226 Rat
FunctionGbetaL (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors (1). It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 2). Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation (reviewed in 3). TOR is normally associated with GbetaL and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis (3). The binding of GbetaL to TOR stimulates TOR’s kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth (3).
Related Pathway mTOR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of GbL in human brain cell lysate with GbL antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of GBL in mouse brain tissue with GBL antibody at 10 ug/ml.

 

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