Home Antibody All anti-FRAP1 antibodies
Also for FRAP1 (NM_004958)
|TOR antibody was raised against a 15 amino acid peptide from near the amino terminus of human TOR.|
||ELISA, WB: 1 - 2 ug/ml, ICC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) (MTOR)|
|FRAP; FRAP1; FRAP2; RAFT1; RAPT1|
Entrez Gene 2475 Human
Entrez Gene 56717 Mouse
|The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1). It was initially discovered as a kinase whose ability to stimulate T cell proliferation in response to IL-2 could be inhibited by the immunosuppressive drug rapamycin (2,3). Rapamycin inhibits TOR in other cell types resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation (reviewed in 4). TOR is normally associated with the regulatory proteins RAPTOR and GbetaL. Its downstream targets are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs). Regulation of these protein families allows TOR to control protein biosynthesis (4).|
|Protein KinaseDruggable Genome ErbB signaling pathwaymTOR signaling pathwayInsulin signaling pathwayAdipocytokine signaling pathwayType II diabetes mellitusPathways in cancerMore Pathways >> |
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Western blot analysis of TOR in L1210 cell lysate with TOR antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of TOR in L1210 cells with TOR antibody at 2 ug/mL.