Home Antibody All anti-CASP7 antibodies
Also for CASP7 (NM_001227)
|Caspase-7 antibody was raised against a 16 amino acid peptide from near the amino-terminus of human Caspase-7.|
|Human, Mouse, Rat
||WB: 0.5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant a|
|CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3|
|Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3 (4). Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms (4). Caspase-7 activity can be directly inhibited by XIAP expression (5).|
MAPK signaling pathway
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Western blot analysis of Caspase-7 in mouse skeletal muscle cell lysate with Caspase-7 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of caspase-7 in rat skeletal muscle tissue with caspase-7 antibody at 10 ug/ml.