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Home Antibody All anti-UBE2N antibodies

Anti-UBE2N Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306183
  • Rabbit Polyclonal UBC13 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418741) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for UBE2N (NM_003348)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenUBC13 antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UBC13.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens ubiquitin-conjugating enzyme E2N (UBE2N)
Alternative NameHEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN
Database LinkNP_003339
Entrez Gene 7334 Human
Entrez Gene 93765 Mouse
Entrez Gene 116725 Rat
FunctionUbiquitin-conjugating enzyme 13 (Ubc13) was initially discovered in S. cerevisiae as a DNA-damage inducible protein involved in the error-free DNA postreplication repair pathway (1). It has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). Ubc13 is part of a dimeric ubiquitin-conjugating enzyme complex also containing UEV1A (ubiquitin-conjugating enzyme E2 variant 1) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).
Related PathwayDruggable Genome Ubiquitin mediated proteolysis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of UBC13 in human small intestine cell lysates with UBC13 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of UBC13 in mouse thymus tissue with UBC13 antibody at 2 ug/ml.

 

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