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Home Antibody All anti-RNF216 antibodies

Anti-RNF216 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306182
  • Rabbit Polyclonal TRIAD3A Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenTRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens ring finger protein 216 (RNF216), transcript variant 1
Alternative NameCAHH; TRIAD3; U7I1; UBCE7IP1; ZIN
Database LinkNP_996994
FunctionActivation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2). Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR (3,4). Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase (5). TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9; this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation (5).
Related Pathway

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WB Image
Western blot analysis of TRIAD3A in mouse heart cell lysates with TRIAD3A antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of TRIAD3A in mouse heart with TRIAD3A antibody at 10 ug/ml.

 

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