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Home Antibody All anti-BID antibodies

Anti-BID Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306178 Rabbit Polyclonal Bid Antibody 100ug $325 3-7 Days
LC420074 BID HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenBid antibody was raised against a peptide corresponding to 14 amino acids near the middle of human Bid.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens BH3 interacting domain death agonist (BID), transcript variant 2
Alternative NameFP497
Database LinkNP_001187
Entrez Gene 637 Human
Entrez Gene 12122 Mouse
FunctionApoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals (4,5), exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein (6). The cleaved complex is myris-toylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize (7,8).
Related PathwayDruggable Genome p53 signaling pathwayApoptosisNatural killer cell mediated cytotoxicityAlzheimer's diseaseAmyotrophic lateral sclerosis (ALS)Pathways in cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Bid in A549 cell lysates with Bid antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml.
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