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Home Antibody All anti-BAX antibodies

Anti-BAX Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306176
  • Rabbit Polyclonal Bax Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenBax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 4 ug/ml, ICC: 2 ug/ml, IF: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens BCL2-associated X protein (BAX), transcript variant beta
Alternative NameBCL2L4
Database LinkNP_004315
Entrez Gene 581 Human
FunctionApoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli (4,5). It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability (6,7).
Related Pathway
Apoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Bax in HL-60 cell lysates with Bax antibody at (A) 1, (B) 2, and (C) 4 ug/mL.
IF Image
Immunocytochemistry staining of HL-60 cells using Bax at 2 ug/mL.

 

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