Home Antibody All anti-ARL6IP1 antibodies
Also for ARL6IP1 (NM_015161)
|ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER.|
||WB: 0.5 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens ADP-ribosylation factor-like 6 interacting protein 1 (ARL6IP1)|
|AIP1; ARL6IP; ARMER; SPG61|
Entrez Gene 23204 Human
Entrez Gene 54208 Mouse
|Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.|
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Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemical staining of human bladder tissue using ARMER antibody at 2 ug/ml.