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Home Antibody All anti-TIRAP antibodies

Anti-TIRAP Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306133
  • Rabbit Polyclonal TIRAP Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC422104) , 20ug Explanation
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(1)
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Also for TIRAP (NM_001039661)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenTIRAP antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 3
Alternative NameBACTS1; Mal; MyD88-2; wyatt
Database LinkNP_001034750
Entrez Gene 114609 Human
Entrez Gene 117149 Mouse
Entrez Gene 680127 Rat
FunctionToll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors (4,5). In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling (6). Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-?B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling (6,7)
Related PathwayDruggable Genome Toll-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of TIRAP in human heart cell lysates with TIRAP antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
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Immunohistochemical staining of human heart cells using TIRAP antibody at 2 ug/ml.
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