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Home Antibody All anti-IRAK4 antibodies

Anti-IRAK4 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306123 Rabbit Polyclonal IRAK-4 Antibody 100ug $325 3-7 Days
LC426473 IRAK4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenIRAK-4 antibody was raised against a synthetic peptide corresponding to amino acids at the carboxy terminus of human IRAK-4.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 4 ug/mL, ICC: 10 ug/mL, IF: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 1
Alternative NameIPD1; IRAK-4; NY-REN-64; REN64
Database LinkNP_001107654
Entrez Gene 51135 Human
FunctionInterleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappaB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4 (4,5). Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges (5,6). Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
Related PathwayProtein KinaseDruggable Genome ApoptosisToll-like receptor signaling pathwayNeurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IRAK-4 in HeLa cell lysate with IRAK-4 antibody at 1 (lane 1), 2 (lane 2), and 4 (lane 3) ug/mL, respectively.

IF Image
Immunocytochemistry of IRAK-4 in K562 cells with IRAK-4 antibody at 10 ug/mL.

IF Image
Immunofluorescence of IRAK-4 in K562 cells with IRAK-4 antibody at 10 ug/mL.


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