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Home Antibody All anti-NLRP2 antibodies

Anti-NLRP2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306102
  • Rabbit Polyclonal NALP2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC413416) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for NLRP2 (NM_017852)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNALP2 antibody was raised against a peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Immunoaffinity chromatography purified IgG

Reference Data

Target NameHomo sapiens NLR family, pyrin domain containing 2 (NLRP2), transcript variant 1
Alternative NameCLR19.9; NALP2; NBS1; PAN1; PYPAF2
Database LinkNP_060322
FunctionNALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli (1). Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD) (2). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1Β-processing activity and is thought to function as a modulator of NF-ΚB and procaspase-1 activation in macrophages (2,3). It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs) (4). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
Related Pathway

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WB Image
Western blot analysis of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 &#956g/ml.

 

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