Home Antibody All anti-NLRP2 antibodies
Also for NLRP2 (NM_017852)
|NALP2 antibody was raised against a peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Immunoaffinity chromatography purified IgG
|Homo sapiens NLR family, pyrin domain containing 2 (NLRP2), transcript variant 1|
|CLR19.9; NALP2; NBS1; PAN1; PYPAF2|
Entrez Gene 55655 Human
Entrez Gene 232827 Mouse
|NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli (1). Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD) (2). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1Β-processing activity and is thought to function as a modulator of NF-ΚB and procaspase-1 activation in macrophages (2,3). It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs) (4). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.|
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Western blot analysis of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 μg/ml.