Home Antibody All anti-TRAF3IP2 antibodies
Also for TRAF3IP2 (NM_001164281)
|CIKS antibody was raised against a synthetic peptide corresponding to amino acids 2 to 15 of human CIKS .|
|WB, IHC, IF
||WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 3|
|ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13|
|Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappaB associates with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. IkappaB is phosphorylated by IkappaB kinase (IKK) complex that contains IKKalpha, IKKbeta, and IKKgamma. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-kappaB activator 1) (1,2). CIKS directly interacts with IKKgamma. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.|
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis of CIKS expression in human lung (lane A) and placenta (lane B) tissue lysates with CIKS antibody at 1 ug /ml.
Immunohistochemistry of CIKS in human lung tissue with CIKS antibody at 5 ug/ml.
Immunofluorescence of CIKS in human lung tissue with CIKS antibody at 20 ug/mL.