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Anti-NKIRAS1 Antibody

WB(1)

IHC(1)

Gene Name Homo sapiens NFKB inhibitor interacting Ras-like 1 (NKIRAS1) Synonyms: kappaB-Ras1; KBRAS1 Immunogen KappaB ras antibody was raised against a 18 amino acid peptide from near the center of human KappaB ras 1. Buffer PBS containing 0.02% sodium azide. Clone Name Isotype IgG Species Reactivity Human, Mouse, Rat Concentration 1ug/ul Purification Affinity chromatography purified via peptide column (Protein A or G Sepharose) Guaranteed Application * WB, IHC Suggested Dilutions WB: 2 - 4 ug/ml Background KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody detects both kappaB-ras1 and kappaB-ras2. Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of NFKB inhibitor interacting Ras-like 1 (NKIRAS1) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • NKIRAS1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • NKIRAS1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Nkiras1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • NKIRAS1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Nkiras1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens NFKB inhibitor interacting Ras-like 1 (NKIRAS1) as transfection-ready DNA • Lenti ORF clone of Human NFKB inhibitor interacting Ras-like 1 (NKIRAS1) , Myc-DDK-tagged • GFP-tagged ORF clone of Homo sapiens NFKB inhibitor interacting Ras-like 1 (NKIRAS1) as transfection-ready DNA • Lenti ORF clone of Human NFKB inhibitor interacting Ras-like 1 (NKIRAS1), mGFP tagged • Myc-DDK-tagged ORF clone of Homo sapiens NFKB inhibitor interacting Ras-like 1 (NKIRAS1) as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens NFKB inhibitor interacting Ras-like 1 (NKIRAS1) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)