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Home Antibody All anti-PCBP4 antibodies

Anti-PCBP4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306079
  • Rabbit Polyclonal MCG10 Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenMCG10 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MCG10.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 1 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens poly(rC) binding protein 4 (PCBP4), transcript variant 5
Alternative NameCBP; LIP4; MCG10
Database LinkNP_001167571
FunctionMCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.
Related Pathway

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WB Image
Western blot analysis of MCG10 in HeLa cell lysate with MCG10 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
IF Image
Immunocytochemistry of MCG10 in HeLa cells with MCG10 antibody at 1 ug/mL.

 

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