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Also for PCBP4 (NM_001174100)
|MCG10 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MCG10.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 1 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens poly(rC) binding protein 4 (PCBP4), transcript variant 5|
|CBP; LIP4; MCG10|
|MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.|
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Western blot analysis of MCG10 in HeLa cell lysate with MCG10 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry of MCG10 in HeLa cells with MCG10 antibody at 1 ug/mL.