Home Antibody All anti-IL21 antibodies
Also for IL21 (NM_021803)
|IL-21 antibody was raised against a synthetic peptide corresponding to 15 amino acids near the center of human IL-21 precursor .|
||0.5~1.0 mg/ml (Lot Dependent)
||ELISA, WB: 1 ug/ml, ICC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens interleukin 21 (IL21), transcript variant 1|
|A novel cytokine was recently identified in human and mouse and designated IL-21 , which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4). IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.|
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
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Western blot analysis of IL-21 expression in HL-60 cell lysate in the absence (lane A) or presence of blocking peptide (lane B) with IL-21 antibody at 1 ug /ml.
Immunocytochemistry of IL-21 in K562 cells with IL-21 antibody at 2 ug/mL.