Home Antibody All anti-TNFRSF17 antibodies
Also for TNFRSF17 (NM_001192)
|BCMA antibody was raised against a synthetic peptide mapping at the carboxy terminus of human BCMA .|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 2 - 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens tumor necrosis factor receptor superfamily, member 17 (TNFRSF17)|
|BCM; BCMA; CD269; TNFRSF13A|
|Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL-2, respectively, (3,5). BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified (6,7). BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.|
Cytokine-cytokine receptor interaction
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Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with BCMA antibody at 5 ug/ml.
Immunohistochemistry of BCMA in human spleen cells with BCMA antibody at 10 ug/ml.