Home Antibody All anti-TNFRSF13B antibodies
Also for TNFRSF13B (NM_012452)
|TACI antibody was raised against a synthetic peptide mapping at the amino terminus of human TACI .|
||ELISA, WB: 5 ug/ml, ICC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B)|
|CD267; CVID; CVID2; RYZN; TACI; TNFRSF14B|
Entrez Gene 23495 Human
|Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL-2, respectively, (3,5). BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified (6,7). TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionPrimary immunodeficiency|
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Western blot analysis of TACI in K562 (A) and U937 (B) cell lysates with TACI antibody at 5 ug/mL.
Immunocytochemistry of TACI in K562 cells with TACI antibody at 2 ug/mL.