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Anti-Ripk3 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306042 Rabbit Polyclonal RIP3 Antibody 100ug $325 In Stock
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OriGene Data

ImmunogenRIP3 antibody was raised against a peptide corresponding to amino acids 473 to 486 of murine RIP3.
Clone Name IsotypeIgG
Species ReactivityMouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameMus musculus receptor-interacting serine-threonine kinase 3 (Ripk3), transcript variant 1
Alternative Name2610528K09Rik; AW107945; Rip3
Database LinkNP_064339
Entrez Gene 56532 Mouse
Entrez Gene 246240 Rat
FunctionCertain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3 (1-3). RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-kappaB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues (2,3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RIP3 in mouse 3T3 whole cell lysate in the absence (A) or presence (B) of blocking peptide with RIP3 antibody at 1 ug/ml.

IHC Image
Immunohistochemistry of RIP3 in rat kidney tissue with RIP3 antibody at 5 ug/ml.

IF Image
Immunofluorescence of RIP3 in Rat Kidney cells with RIP3 antibody at 20 ug/mL.


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