Home Antibody All anti-SNW1 antibodies
Also for SNW1 (NM_012245)
|SkiP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human SkiP .|
|Human, Mouse, Rat
||ELISA, WB: 0.5 - 1 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens SNW domain containing 1 (SNW1)|
|Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP|
Entrez Gene 22938 Human
Entrez Gene 66354 Mouse
Entrez Gene 500695 Rat
|TGF-beta and the bone morphogenic proteins (BMPs) are key signaling proteins that regulate numerous cellular processes such as embryonic development and tumorigenesis (1). Both signal through the Smad protein family and are negatively regulated by Ski and SnoN, two related proto-oncoproteins (2,3). Ski functions by binding to the Smad proteins activated by TGF-beta and the (BMPs) and preventing their phosphorylation, inhibiting their ability to bind DNA and activate the transcription of downstream genes (4,5). SkiP was originally identified as a Ski-interacting protein (6) and was later found to augment the signals induced by TGF-beta but inhibit transcription induced by BMP-2 (7) in C2C12 cells, suggesting that SkiP is a key player in the signaling cascades inititated by TGF-beta and the BMP protein family.|
|Transcription FactorsDruggable Genome SpliceosomeNotch signaling pathway|
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Western blot analysis of SkiP in mouse skeletal muscle tissue lysate with SkiP antibody at (A) 0.5 and (B) 1 ug/mL.
Immunofluorescence of Ski in human kidney tissue with Ski antibody at 20 ug/mL.