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Home Antibody All anti-SNW1 antibodies

Anti-SNW1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306036 Rabbit Polyclonal SkiP Antibody 100ug $325 3-7 Days
LC402178 SNW1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenSkiP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human SkiP .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 - 1 ug/mL, ICC: 20 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens SNW domain containing 1 (SNW1), transcript variant 2
Alternative NameBx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP
Database LinkNP_036377
Entrez Gene 22938 Human
Entrez Gene 66354 Mouse
Entrez Gene 500695 Rat
FunctionTGF-beta and the bone morphogenic proteins (BMPs) are key signaling proteins that regulate numerous cellular processes such as embryonic development and tumorigenesis (1). Both signal through the Smad protein family and are negatively regulated by Ski and SnoN, two related proto-oncoproteins (2,3). Ski functions by binding to the Smad proteins activated by TGF-beta and the (BMPs) and preventing their phosphorylation, inhibiting their ability to bind DNA and activate the transcription of downstream genes (4,5). SkiP was originally identified as a Ski-interacting protein (6) and was later found to augment the signals induced by TGF-beta but inhibit transcription induced by BMP-2 (7) in C2C12 cells, suggesting that SkiP is a key player in the signaling cascades inititated by TGF-beta and the BMP protein family.
Related PathwayTranscription FactorsDruggable Genome SpliceosomeNotch signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of SkiP in mouse skeletal muscle tissue lysate with SkiP antibody at (A) 0.5 and (B) 1 ug/mL.

IF Image
Immunofluorescence of Ski in human kidney tissue with Ski antibody at 20 ug/mL.


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