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Home Antibody All anti-RIPK2 antibodies

Anti-RIPK2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306013
  • Rabbit Polyclonal RICK Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC418408) , 20ug
100ug $325 3-7 Days
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WB(1)
IF(1)
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Also for RIPK2 (NM_003821)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRICK antibody was raised against a peptide corresponding to amino acids 508 to 522 of human origin .
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:500
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens receptor-interacting serine-threonine kinase 2 (RIPK2)
Alternative NameCARD3; CARDIAK; CCK; GIG30; RICK; RIP2
Database LinkNP_003812
FunctionApoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues (1).
Related Pathway

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WB Image
Western blot analysis of RICK in A431 cell lysate with RICK antibody at (A) 1 and (B) 2 µg/ml.
IF Image
Immunocytochemistry of RICK in K562 cells with RICK antibody at 5 µg/ml

 

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