Home Antibody All anti-RIPK2 antibodies
Also for RIPK2 (NM_003821)
|RICK antibody was raised against a peptide corresponding to amino acids 508 to 522 of human origin .|
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens receptor-interacting serine-threonine kinase 2 (RIPK2)|
|CARD3; CARDIAK; CCK; GIG30; RICK; RIP2|
|Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues (1).|
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Western blot analysis of RICK in A431 cell lysate with RICK antibody at (A) 1 and (B) 2 µg/ml.
Immunocytochemistry of RICK in K562 cells with RICK antibody at 5 µg/ml