Invalid object name 'antibody_LocusMapping'. Anti-TNFRSF6B Antibody, - OriGene
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Anti-TNFRSF6B Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306004
  • Rabbit Polyclonal DcR3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC429165) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TNFRSF6B (NM_003823)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenDcR3 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human DcR3 precursor.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500 - 1:1000
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B)
Alternative NameDCR3; DJ583P15.1.1; M68; M68E; TR6
Database LinkNP_003814
FunctionApoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively, (1,2). Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis (1,2). DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.
Related Pathway
Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DcR3 in human heart (H), brain (B), and kidney (K) tissue lysates with DcR3 antibody at 1:500 dilution.
IHC Image
Immunohistochemistry of DcR1 in human heart tissue with DcR1 antibody at 1 ug/ml.

 

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