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Home Antibody All anti-IRAK2 antibodies

Anti-IRAK2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305997
  • Rabbit Polyclonal IRAK-2 Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenIRAK2 antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human IRAK2.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interleukin-1 receptor-associated kinase 2 (IRAK2)
Alternative NameIRAK-2
Database LinkNP_001561
Entrez Gene 3656 Human
FunctionThe pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappaB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2 . Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappaB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappaB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.
Related PathwayProtein KinaseDruggable Genome ApoptosisNeurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IRAK2 in HeLa (H) and K562 (K) whole cell lysate with IRAK2 antibody (C2) at 2 ug/mL.
IF Image
Immunocytochemical staining of HeLa cells using IRAK2 antibody at 2 ug/mL.

 

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